Studies in selected areas

Helplifes has spent more than forty years investigating the safety and efficacy of our probiotic strains. We conduct state-of-the-art preclinical and clinical studies, to evaluate the health effects and underlying mechanisms of our probiotics. Our scientists, and research groups, have published hundreds of studies on functional probiotics, covering various fields from digestive health to chronic disease management health.

Beneath we present a few of our studies in selected areas.

Bifidobacterium longum CCFM760

Function: Relieve constipation

Article: Physiological Characteristics, Safety Evaluation and Genetic Analysis of Bifidobacterium longum CCFM760

Screening and Probiotic Characteristics Analysis of Bifidobacteria with Relieving Constipation

Author: Ying Congping

Journal: Journal of Food Science and Biotechnology Vol.39 Issue 2 2020

Lactobacillus plantarum CCFM1143

Function: Protective effect on diarrhea

Article: Lactobacillus plantarum relieves diarrhea caused by enterotoxin-producing Escherichia coli through inflammation modulation and gut microbiota regulation

Author: Yue Yue

Journal: Food & Function 2020

Bifidobacterium longum subsp. longum YS108R

Function: Alleviates DSS-induced colitis

Article: A ropy exopolysaccharide producing strain Bifidobacterium longum subsp. longum YS108R alleviates DSS-induced colitis by maintenance of the mucosal barrier and gut microbiota modulation

Author: Shuang Yan

Journal: Food & Function 2019

Lactobacillus gasseri Chen, and L. plantarum 18

Function: Significant anti-H.pylori activity

Article: Antagonistic Activities of Lactobacilli against Helicobacter pylori Growth and Infection in Human Gastric Epithelial Cells

Author: Xiaohua Chen

Journal: Journal of Food Science

Bacillus coagulans-39

Function: relieved constipation

Article: MLST analysis of genetic diversity of Bacillus coagulans strains to evaluate effects on constipation model

Author: Jiang Cao

Journal: Food science and Human Wellness

Bifidobacterium longum subspecies infantis CCFM687

Function: Alleviate depressive behaviors and neurological abnormalities 

Article: Ingestion of Bifidobacterium longum subspecies infantis strain CCFM687 regulated emotional behavior and the central BDNF pathway in chronic stress-induced depressive mice through reshaping the gut microbiota

Author: Peijun Tian 

Journal: Food & Function 2019

Bifidobacterium longum subsp. infantis E41 and Bifidobacterium breve M2CF22M7

Function: Treatment on depression 

Article: Bifidobacterium with the role of 5-hydroxytryptophan synthesis regulation alleviates the symptom of depression and related microbiota dysbiosis

Author: Peijun Tian 

Journal: Journal of Nutritional Biochemistry 66 (2019) 43–51

Lactobacillus brevis DL1-11

Function: High GABA-producing capacity,alleviated anxiety and improve sleep,decreases in anxiety behavior 

Article: Beneficial effect of GABA-rich fermented milk on insomnia involving T regulation of gut microbiota 

Author: Leilei Yu 

Journal: Microbiological Research 233 (2020) 126409

Bifidobacterium breve CCFM1026

Function: Relieving respiratory infections

Article: The Potential Role of Probiotics in Protection against Influenza a Virus Infection in Mice

Author: Wenwei Lu

Journal: Foods 2021 Apr 20

Streptococcus thermophilus CCFM218 (ST218)

Function: Alleviate allergic responses treated with antibiotics

Article: Oral application of lactic acid bacteria following treatment with antibiotics inhibits allergic airway inflammation

Author: Q. Zhang

Journal: Journal of Applied Microbiology 119, 809–817 © 2015

Lactobacillus reuteri CCFM1072 and CCFM1040

Function: Alleviate allergic asthma

Article: Lactobacillus reuteri CCFM1072 and CCFM1040 with the role of Treg cells regulation alleviate airway inflammation through modulating gut microbiota in allergic asthma mice

Author: Lingzhi Li

Journal: Journal of Functional Foods 2020-11

Bifidobacterium longum CCFM1029

Function: Alleviate 2, 4-dinitrofluorobenzene-induced AD

Article: Strain-specific ameliorating effect of Bifidobacterium longum on atopic dermatitis in mice

Author: Zhifeng Fang

Journal: Journal of Functional Foods

Lactobacillus plantarum LP01/ Lactobacillus paracasei LPC00

Function: Treatment of Allergic Rhinitis

Article: Multi-strain Symbiotic Preparations as a Novel Adjuvant Approach to Allergic Rhinitis

Author: Giuseppina Manzotti

Journal: Columbia International Publishing Journal of Contemporary Immunology Oct-14

Lactococcus lactis LL- DM

Function: Alleviated Der p2-induced airway inflammation,inhibit allergic responses

Article: Suppression of dust mite allergy by mucosal delivery of a hypoallergenic derivative in a mouse model

Author: Chunqing Ai

Lactobacillus casei  CCFM1074

Function: Alleviates Collagen-Induced Arthritis

Author: Zhexin Fan

Article: Lactobacillus casei CCFM1074 Alleviates Collagen-Induced Arthritis in Rats via Balancing Treg/Th17 and Modulating the Metabolites and Gut Microbiota

Journal: Frontiers in immunology 2021

Bifidobacterium animalis CCFM1148

Function: Ameliorate psoriasis.

Author: Yadan Deng

Article: Evaluation of probiotics for inhibiting hyperproliferation and inflammation relevant to psoriasis in vitro

Journal: Journal of Functional Foods 2021

Lactobacillus rhamnosus CCFM0528

Function: A promising therapeutic agent in treating type 2 diabetes 

Article: Oral administration of Lactobacillus rhamnosus CCFM0528 improves glucose tolerance and cytokine secretion in high-fat-fed, streptozotocin-induced type 2 diabetic mice 

Author: Pei Chen 

Journal: journal of functional foods 10 (2014) 318–326

Lactobacillus casei CCFM0412

Function: Prevention of type 2 diabetes. 

Article: Antidiabetic effect of Lactobacillus casei CCFM0412 on mice with type 2 diabetes induced by a high-fat diet and streptozotocin

Author: Pei Chen 

Journal: Nutrition 2012

Lactobacillus fermentum 5-1L

Function: Relieving osteoporosis

Article: Development and functional evaluation of probiotics with the effect of relieving osteoporosis

Author: Jiang Peng

Lactobacillus rhamnosus L7-1 

Function: alleviate non-alcoholic fatty liver disease

Article: Bifidobacterium adolescentis and Lactobacillus rhamnosus alleviate non-alcoholic fatty liver disease induced by a high-fat, high-cholesterol diet through modulation of different gut microbiota-dependent pathways

Author: Gang Wang

Journal: Food & Function 2020

Lactobacillus crispatus CCFM1110

Function: Prevention and/or treatment of candida vaginitis

Article: A strain of Lactobacillus crispatus that prevents and/or treats candida vaginitis.

Comparative Genomics of Lactobacillus crispatus from the Gut and Vagina Reveals Genetic Diversity and Lifestyle Adaptation.

Lactobacillus crispatus inhibiting Candida albicans proliferation and regulating immune response to alleviate vulvovaginal candidiasis

Author: Qiuxiang Zhang

Journal: Genes 2020,11,360

Lactobacillus gasseri CCFM1213

Function: Inhibit gardnerella vaginalis

Article: Inhibitory effect of Lactobacillus gasseri CCFM1213 on Gardnerella vaginalis in mice with bacterial vaginosis

Lactobacillus plantarum CCFM1019 (Lactobacillus plantarum HL2)

Function: Alleviates polycystic ovary syndrome

Article: Lactobacillus plantarum CCFM1019 attenuate polycystic ovary syndrome through butyrate dependent gut-brain mechanism

Bifidobacterium longum CCFM1102 (Bifidobacterium longum HB3)

Function: Alleviates polycystic ovary syndrome

Article: Lactic acid bacteria alleviate polycystic ovarian syndrome by regulating sex hormone related gut microbiota

Author: Yufeng He

Journal: Food & Function 2020

Lactobacillus plantarum CCFM1180 (Lactobacillus plantarum 30M5 )

Function: Relieve the symptoms of female menopause caused by estrogen deficiency

Article: Modulation of the gut microbiota structure with probiotics and isoflavone alleviates metabolic disorder in ovariectomized mice

Author: Qian Chen

Journal: Nutrients 2021,13,1793

Lactobacillus plantarum CCFM8724

Function: Treatment and prevention of dental caries induced by S. mutans and C. albicans.

Article: Inhibitory Effect of Lactobacillus plantarum CCFM8724 towards Streptococcus mutans- and Candida albicans-Induced Caries in Rats

Author: Qiuxiang Zhang

Journal: Oxidative Medicine and Cellular Longevity  2020

Lactobacillus fermentum CCFM1139

Function:  protect against periodontitis

Article: Effects of Limosilactobacillus fermentum CCFM1139 on experimental periodontitis in rats

Author: Qiuxiang Zhang

Journal: Food & Function 2021